panoramatest.comPanorama Prenatal Screening Test | Fetal Genetic Testing

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Panorama uses unique SNP*-based technology to deliver the most accurate NIPT on the market. Tests For: Common chromosomal abnormalities When is it done? 9+ weeks Turn Around Time: 5 - 7 days Why choose Panorama for fetal genetic testing? Clinical advantages of genetic testing for pregnancy Panorama detects conditions that other tests cannot, including molar pregnancy, triploidy and vanishing twin. Panorama screens for Down syndrome with an accuracy rate greater than 99%. Panorama is the only test that differentiates between maternal and fetal DNA, which helps avoid false positives and false negatives. Panorama is the only NIPT that can assess zygosity, individual fetal sex, and individual fetal fraction* in twin pregnancies. Panorama has the highest sensitivity for 22q11.2 deletion syndrome, a common and potentially severe microdeletion that impacts pregnancies equally regardless of maternal age. Panorama can be performed for singleton, twin, egg donor, and surrogate pregnancies. *For dizygotic twins only A Trusted Resource More than 2 million women in more than 60 countries have chosen Panorama for genetic testing during pregnancy. Panorama has been evaluated in 21 peer-reviewed, publications and in more than 1.3 million pregnancies. Panorama offers complimentary pre- and post-test information sessions with board-certified genetic counselors. Panorama poses no risk to the baby compared to amniocentesis or chorionic villus sampling (CVS). Download: Physician Brochure Panorama offers prenatal screening for twin, egg donor, and surrogate pregnancies! Conditions screened in twin, egg donor, and surrogate pregnancies: Trisomy 21 Trisomy 18 Trisomy 13 Sex chromosome trisomies (reported when seen)* 22q11.2 deletion syndrome (optional)* * Available only for monozygotic twins Conditions Screened During Single Nucleotide Polymorphism Testing Panorama screens for common genetic conditions that are caused by extra or missing chromosomes in the baby’s DNA. Because Panorama uses a unique technology to truly distinguish between the mother's and the baby's DNA, it is the only NIPT that tests for triploidy, and it has the highest accuracy in determining the sex of the baby (optional). Some conditions, such as Down syndrome, are caused by extra copies of a specific chromosome. Others, such as microdeletions, occur when a chromosome is missing a small piece of genetic information. Microdeletions affect pregnancies equally, regardless of maternal age. TRISOMIES Trisomy 21 (Down syndrome) Babies with Down syndrome have three copies of chromosome 21 and have intellectual disabilities that range from mild to severe. Children with Down syndrome will need extra medical care depending on the child’s specific health problems. Early intervention has allowed many individuals with Down syndrome to lead healthy and productive lives. The presence of medical conditions, like heart defects, can affect the lifespan in these children and adults; however, most individuals with Down syndrome will live into their 60s. Miscarriage occurs in about 30% of pregnancies with Down syndrome while overall about 1 in 700 babies are born with Down syndrome. Trisomy 18 (Edwards syndrome) Babies with trisomy 18 have three copies of chromosome 18 and have severe intellectual disabilities and birth defects typically involving the heart, brain, and kidneys. Babies with trisomy 18 can also have visible birth defects such as an opening in the lip (cleft lip) with or without an opening in the roof of the mouth (cleft palate), small head, clubbed feet, underdeveloped fingers and toes, and a small jaw. Unfortunately, most pregnancies with trisomy 18 will miscarry. If born alive, most affected babies with trisomy 18 will pass away within the first few weeks of life. About 10 percent survive to their first birthday. Trisomy 18 occurs in approximately 1 in 3,000 live births. Trisomy 13 (Patau syndrome) Babies with trisomy 13 have three copies of chromosome 13 and have severe intellectual disabilities. They often have birth defect involving the heart, brain, and kidneys. Visible abnormalities include extra fingers and/or toes or an opening in the lip, with or without an opening in the palate. Given the severe disabilities, most pregnancies affected by trisomy 13 will miscarry. If born alive, most affected babies with trisomy 13 will pass away within the first few weeks of life. About 10 percent survive to their first birthday. Trisomy 13 occurs in approximately 1 in 5,000 live births. SEX CHROMOSOME ABNORMALITIES Monosomy X (Turner syndrome) Babies with monosomy X are females who have one X chromosome instead of two. Unfortunately, a high proportion of pregnancies with monosomy X will result in a miscarriage in the first or second trimester of pregnancy. Babies with monosomy X that make it to term may have heart defects, learning difficulties, and infertility. In most cases, girls with monosomy X will need extra medical care including hormone therapy at various stages of life. Klinefelter syndrome Boys with Klinefelter syndrome have an extra X chromosome (XXY). This condition can be associated with learning difficulties and behavioral problems. Men with Klinefelter syndrome may be infertile. About 1 in 1,000 babies will be born with Klinefelter syndrome. Triple X syndrome Girls with Triple X syndrome have an extra X chromosome (XXX). Girls with this condition may be taller than average and may experience learning difficulties or behavioral problems. Approximately 1 in 800 girls will be born with an extra X chromosome. Jacob’s syndrome Boys with Jacob’s syndrome have an extra Y chromosome (XYY). Most babies with XYY syndrome do not have any birth defects. Boys with XYY may be taller than average and have an increased risk for learning, speech, and behavioral problems. Approximately 1 in 650 boys will be born with an extra Y chromosome. Microdeletions* 22q11.2 deletion syndrome 22q11.2 deletion syndrome, also called DiGeorge syndrome or Velo-Cardio-Facial syndrome (VCFS), is caused by a missing piece of chromosome number 22. About one in every 2,000 babies is born with 22q11.2 deletion syndrome. The majority of children with this disorder have heart defects, immune system problems, and specific facial features. Most children with 22q.11.2 deletion syndrome have mild-to-moderate intellectual disability and speech delays; some will also have low calcium levels, kidney problems, feeding problems and/or seizures. About one in five children with 22q11.2 deletion syndrome have autism spectrum disorder; 1 in 4 adults with 22q11.2 deletion syndrome have a psychiatric illness, like schizophrenia. Prader-Willi syndrome Prader-Willi syndrome occurs when either a small piece of chromosome 15 is missing or when both copies of chromosome 15 come from the same parent (called uniparental disomy, or UPD). Babies with Prader-Willi syndrome have low muscle tone and problems with growth and feeding. Children with Prader-Willi syndrome have delayed milestones, short stature, rapid weig...